TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection
نویسندگان
چکیده
منابع مشابه
Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection
Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...
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Negative Factor, Nef Yes, cleaved by PR CD4/MHC downregulation; T-cell activation; moderate enhancer of viral infectivity; blocks apoptosis; pathogenicity determinant CD4, CD28, MHC-I, MHC-II, TCR-CD3ζ, other cell-surface proteins Nef connects immunologically important host surface proteins to clathrin-dependent and -independent sorting pathways to regulate traffi cking, degradation, and immune...
متن کاملAcute HIV-1 Infection.
From the Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill (M.S.C.), and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham (B.F.H.) — both in North Carolina; the University of Alabama at Birmingham, Birmingham (G.M.S.); and the Weatherall Institute of Molecular Medicine and the National Institute for Health Re...
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2557 tives on racial and ethnic differences in health in late life. Washington, D.C.: National Academies Press, 2004:643-74. 3. HIV/AIDS surveillance report. Vol. 8. No. 2. Atlanta: Centers for Disease Control and Prevention, 1996:28. 4. HIV/AIDS surveillance report. Vol. 15. Atlanta: Centers for Disease Control and Prevention, 2003:12. 5. Jaffe H. Whatever happened to the U.S. AIDS epidemic? S...
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Members of the APOBEC family of cellular polynucleotide cytidine deaminases, most notably APOBEC3G and APOBEC3F, are potent inhibitors of HIV-1 infection. Wild type HIV-1 infections are largely spared from APOBEC3G/F function through the action of the essential viral protein, Vif. In the absence of Vif, APOBEC3G/F are encapsidated by budding virus particles leading to excessive cytidine (C) to ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.00482